End Stage Renal Failure on Dialysis
Conditions
Brief summary
Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients receiving conventional treatment. This proposal will test the effect of a new method designed to improve the removal of protein-bound solutes during dialysis. The effects on blood chemical levels of two different dialysis prescriptions will be tested in patients already undergoing nocturnal in-center hemodialysis three times weekly.
Interventions
OTHERlow dialysate flow, smaller dialyzer
The subject will receive dialysis on the usual schedule and for the usual time but with a lower than usual dialysate flow and small dialyzer.
OTHERhigh dialysate flow, larger dialyzer
The subject will receive dialysis on the usual schedule and for the usual time but with a higher than usual dialysate flow and large dialyzer.
Sponsors
Palo Alto Veterans Institute for Research
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* stable on nocturnal in-center dialysis located close to Stanford University and VA Palo Alto
Exclusion criteria
* recent use of antibiotics * gastrointestinal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma levels of the chemical p-cresol sulfate | Participants will be followed for 2-3 weeks on different dialysis prescriptions and plasma chemical levels will be measured at the end of this period. |
Countries
United States
Contacts
Primary Contacttim meyer, md
Outcome results
None listed