BPH( Benign Prostate Hyperplasia), TURP(Transurethral Resection of Prostate)
Conditions
Brief summary
Epidural lidocaine is widely used in anesthesia for urologic or lower abdominal surgery because of its rapid onset. But the epidural anesthesia using high concentration of lidocaine may cause excessive motor block and unwanted side effects such as nausea, vomiting and hypotension. This is a study to determine the effective concentration of lidocaine with fentanyl in lumbar epidural anesthesia for transurethral resection of prostate in elderly patients.
Interventions
DRUGepidural block with lidocaine and fentanyl
The study method was a step-up/step-down sequence model where the dose for following patients was determined by the outcome of the preceding block. The starting concentration of lidocaine was 1.5 % mixed with fentanyl 75 ug. All patients receive 13mL of lidocaine with fentanyl 75ug. The concentration of lidocaine for subsequent patients is determined by the outcome in the previous patient according to up and down sequential allocation in 0.1% increments. In the case of block failure, the concentration of lidocaine was increased by 0.1%. Conversely, block success resulted in a reduction in concentration by 0.1%.
Sponsors
Yonsei University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
65 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* ASA 1 -3, patients scheduled for TURP( transurethral resection of prostate) were included
Exclusion criteria
* Patients with any contraindication to epidural anesthesia were excluded. * cognitive impairment * coagulopathy * allergy to lidocaine * infection at the puncture site
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determining the effective concentration of lidocaine with fentanyl in lumbar epidural anesthesia for transurethral resection of prostate(TURP) in elderly patients | A blinded Assistant assess sensory and motor blockade in a 2-min intervals up to 60 minutes. | The occurrence of sensory block up to at T 12 and motor function score of 3 or more on the modified Bromage scale were considered characteristics of a successful block. Moreover, the surgery should be concluded without any complementary analgesia to confirm the success of the anesthetic procedure. |
Countries
South Korea
Outcome results
None listed