Histologic Response to UVA and UVB Exposure During the Use of Sunscreen

Histologic Response to UVA and UVB Exposure During the Use of Sunscreen With Anti-inflammatory and Anti-oxidant Properties - A Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01892150

Enrollment

Registered

2013-07-04

Start date

2013-03-31

Completion date

2013-07-31

Last updated

2014-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Solar Elastosis

Brief summary

Anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Detailed description

Premature aging can be prevented by using sunscreen. Currently, anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Interventions

OTHERSunscreen

Apply sunscreen before and after UVA and UVB irradiation

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

35 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* subjects aged 35-65 years who were scheduled for abdominoplasty * the excised area should be larger than 18x10 cm2 * no skin diseases or lesions on the excised area * no topical treatment on excised area more than 1 month prior to this study

Exclusion criteria

* pregnancy * lactation * have tattoo or striae distensae on abdomen

Design outcomes

Primary

Measure	Time frame	Description
H&E Staining	2 Months	Review difference in H&E staining in tissue biopsy before and after UVA / UVB irradiation

Secondary

Measure	Time frame	Description
Tyrosinase Staining	2 Months	Review difference in Tyrosinase staining in tissue biopsy before and after UVA / UVB irradiation to evaluate the effects of pigment darkening after UV exposure

Other

Measure	Time frame	Description
8-OH-dG Staining	2 Months	Review difference in 8-OH-dG staining in tissue biopsy before and after UVA / UVB irradiation to evaluate the quantity of free radical species after UV exposure
MMP1 Staining	2 Months	Review difference in MMP1 staining in tissue biopsy before and after UVA / UVB irradiation to evaluate the collagen and ground substances destruction after UV exposure

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026