Nutritional Deficiencies, Obesity
Conditions
Keywords
Obesity, Gastric bypass, Energy balance, Nutritional status, Protein balance
Brief summary
This study is aimed at assessing how Roux-en-Y gastric bypass (RYGP) impacts on energy and nutrients' intake, energy expenditure, and nutritional status in obese patients. It will try quantitate energy and protein balance after RYGP, and to identify how RYGP effects the intake of various common dietary protein sources 16 female patients with BMI \> 40 kg/m2 and on a waiting list for bariatric surgery will be included. The following measurements will be performed before, and 1, 3, 6, 12, and 36 months after RYGP * body weight * body composition (bio impedancemetry) * basal metabolic rate (open circuit indirect calorimetry) * 24-hour urinary urea excretion * fasting blood chemistry * energy and macronutrient's intake (3-day dietary recall)
Interventions
PROCEDURERoux-en-Y gastric bypass (RYGP)
Sponsors
University of Lausanne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* age 18-65 years * gender: females * body mass index \>35 kg/m2
Exclusion criteria
* GI tract diseases * endocrine diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in daily dietary protein intake | measurements obtained baseline , and 1,3, 6, 12, 36 months after surgery | changes in 24-hour protein intake will be evaluated by 7-day food diary; portion size will be assessed with the use of photographs from the SU.VI.MAX study |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in total energy intake | measurements obtained baseline , and 1,3, 6, 12, 36 months after surgery | changes in 24-hour energy intake will be evaluated by 7-day food diary; portion size will be assessed with the use of photographs from the SU.VI.MAX study |
| changes in basal metabolic rate | measurements obtained baseline , and 3, 6, 12, 36 months after surgery | BMR will be measured by indirect calorimetry over a 45-90 min period |
Other
| Measure | Time frame | Description |
|---|---|---|
| changes in fasting, resting respiratory exchange ratio | measurements obtained baseline, and 3, 6, 12, and 36 months after RYGP | measurement will be obtained by indirect calorimetry |
| changes in 24-hour urinary urea excretion | Measurements obtained baseline , and 3, 6, 12, 36 months after RYGP | 24-hour urine collections |
Countries
Switzerland
Outcome results
None listed