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The Antipyretic Efficacy of Oral and Intravenous Paracetamol and Intramuscular Diclofenac in Patients Presenting With Fever.

A Randomized Controlled Clinical Trial on the Antipyretic Efficacy of Oral Paracetamol, Intravenous Paracetamol and Intramuscular Diclofenac in Patients Presenting With Fever to Emergency Department

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01891435
Enrollment
434
Registered
2013-07-03
Start date
2010-01-31
Completion date
2013-04-30
Last updated
2013-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fever, Reduction in Temperature

Keywords

antipyretics, oral paracetamol, intravenous paracetamol, intramuscular diclofenac, emergency department

Brief summary

A randomized clinical trial to check the antipyretic efficacy of oral and intravenous paracetamol and intramuscular diclofenac sodium in patients presenting with fever to emergency department.

Interventions

DRUGOral paracetamol

after giving medicine temperature is checked every 30 minutes for 2 hours

DRUGIntravenous paracetamol

after giving medicine temperature is checked every 30 minutes for 2 hours

DRUGIntramuscular diclofenac

after giving medicine temperature is checked every 30 minutes for 2 hours

Sponsors

Hamad Medical Corporation
Lead SponsorINDUSTRY

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
14 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* Adults between the age of 14-75 years with an oral temperature of more than 38.5 C

Exclusion criteria

* History of allergy to any of the drugs in the study * Had taken antipyretics within 8 hours * Renal, hepatic or haematological disorders * bronchial asthma, peptic ulcer disease, vomiting * Pregnant or lactating women

Design outcomes

Primary

MeasureTime frameDescription
Reduction in temperature in every thirty minutes till 120 minutes after receiving antipyreticsReduction in temperature is checked every 30 minutes for a maximum of 120 minutesOnce the patients fulfill the inclusion criteria, they are randomly assigned to receive one of the three medications in the study ( oral paracetamol, intravenous paracetamol or intramuscular diclofenac). Baseline temperature is recorded using a standard thermometer. Then reduction in temperature is recorded every 30 minutes for 2 hours.

Countries

Qatar

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026