Chronic Traumatic Encephalopathy (CTE), Dementia, Mild Cognitive Impairment (MCI), Post-traumatic Stress Disorder (PTSD), Traumatic Brain Injury (TBI)
Conditions
Keywords
Dementia, Traumatic brain injury (TBI), Mild cognitive impairment (MCI), Chronic traumatic encephalopathy (CTE), Remote effects of TBI, Post-traumatic stress disorder (PTSD_
Brief summary
The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI) among residents of the Armed Forces Retirement Home, Washington D.C. and the Veterans Home of California-Yountville. Investigators will compare the characteristics of dementia in those who have had a prior TBI to the characteristics in those without a history of TBI. It is our hypothesis that the dementia or MCI among those with prior TBI has distinct neuropsychological features that distinguishes it from those with dementia or MCI without a history of TBI.
Detailed description
75 participants with a history of TBI will be the cases (exposed) group. A control group of 75 retirement home residents without a history of TBI who are age-matched to the cases will also be recruited. Participants will be evaluated in a single visit, which will include neurological, psychiatric, and cognitive assessment. The evaluation will take approximately 4 hours. In some cases, the evaluation may be split into two 2 hour sessions.
Interventions
None listed
Sponsors
University of California, San Francisco
Uniformed Services University of the Health Sciences
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
50 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
Cases (with a history of TBI): 1. Ages 50-95 years 2. History of traumatic brain injury of sufficient severity to have resulted in medical attention (ascertained via the Ohio State University TBI Identification Questionnaire-OSU TBI-ID, and based on DoD/VA criteria) 3. Residence in AFRH-Washington D.C. or the Veterans Home of California-Yountville 4. MMSE score ≥ 20 5. Capacity to provide consent to participate in research (assessment made by study physician) 6. Ability to read and write English Controls (without a history of TBI): 1. Ages 50-95 years 2. No history of traumatic brain injury of sufficient severity to have resulted in medical attention (ascertained via the Ohio State University TBI Identification Questionnaire-OSU TBI-ID) 3. Residence in AFRH-Washington or the Veterans Home of California-Yountville 4. MMSE score ≥ 20 5. Capacity to provide consent or assent to participate in research 6. Ability to read and write English -
Exclusion criteria
Cases (with a history of TBI): 1. History of penetrating brain injury 2. History of disabling neurological or psychiatric condition such as epilepsy (besides posttraumatic epilepsy), multiple sclerosis, cortical stroke, hypoxic-ischemic encephalopathy, encephalitis, or schizophrenia Controls (without a history of TBI): History of disabling neurological or psychiatric condition such as epilepsy, multiple sclerosis, cortical stroke, hypoxic-ischemic encephalopathy, encephalitis, or schizophrenia \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of dementia or MCI in the two groups (TBI versus no TBI) | Single visit, 4 hours. | The primary outcome will be the prevalence of dementia/MCI in the two groups (i.e. those with and without a TBI). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Characterization of the types of dementia or MCI that occur in the two groups (TBI or no TBI) | Single visit, 4 hours. | The characterization of the dementia and cognitive impairment within the two groups based on the neuropsychological testing will be secondary outcomes of the study. |
Countries
United States
Outcome results
None listed