Bipolar Disorder, Major Depressive Disorder
Conditions
Keywords
Depression, Treatment, Transcranial electrical stimulation, Maintenance
Brief summary
Transcranial electrical stimulation (TES) techniques offer a novel treatment approach for depression and have shown promising efficacy. However, there is no published data to date on their effectiveness as a maintenance treatment. This study will investigate ways of using TES as a maintenance treatment to prevent relapse in depression.
Interventions
DEVICETranscranial electrical stimulation
Sponsors
The University of New South Wales
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All participants will be ≥ 18 years old. * Participants must have experienced a significant clinical response, defined as ≥ 50% decrease from baseline scores on the Montgomery Asberg Depression Rating Scale (MADRS).
Exclusion criteria
* Inadequate response to acute trial of TES. * Suicidality. * Clinically defined neurological disorder or insult. * Metal in the cranium, skull defects, or skin lesions on scalp (cuts, abrasions, rash) at proposed electrode sites. * Pregnancy (women of childbearing age will be asked to undergo a urine pregnancy test prior to starting the study). * Concurrent long acting benzodiazepines, ritalin or dexamphetamine medication. * Treatment for depression is changed during months 3-9 of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery Asberg Depression Rating Scale for Depression (MADRS) | 9 months |
Countries
Australia
Outcome results
None listed