Longitudinal Study of Traumatic Brain Injury (TBI) in (University of Florida) UF Athletes

Diffusion Tensor Imaging (DTI) Compared to Serum Biomarkers and Standard Clinical Measures of Concussion in Female and Male Collegiate Athletes: a Longitudinal Survey Across the College Years.

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01890304

Acronym

GATOR TBI

Enrollment

750

Registered

2013-07-01

Start date

2013-07-31

Completion date

2018-06-20

Last updated

2021-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic Brain Injury

Keywords

Traumatic Brain Injury, TBI, Concussion, Sports related injury

Brief summary

To identify the changes in the brain following repeated sports-related concussion in men's football, women's soccer, and women's lacrosse college athletes by reviewing the findings of MRI studies that look at the structure of the brain and the appearance of the white matter at baseline, during the acute phase of a concussive injury, and upon completion of collegiate athletic play and correlate these findings with standard clinical measures.

Detailed description

This proposal seeks to study Diffusion Tensor Imaging and functional MRI of the brain at 1) baseline, 2) after concussion and 3) at the end of an athlete's college career. Findings will be compared to standard clinical measures already performed in the management of concussion at the University of Florida Athletic Association and to serum biomarkers already being obtained as part of a UF/ Banyan Biomarker Study. As in the biomarker study, UF athletes on teams with higher incidences of sports related concussion; men's football, women's soccer, and women's lacrosse will be offered enrollment. Longitudinal examinations will allow identification and quantification of concussive DTI findings as comparisons can be made to the individual athlete's baseline data. This will provide valuable correlation of imaging findings with severity of clinical symptoms at the time of injury and also with timing of return to play.

Interventions

OTHERMagnetic Resonance Imaging (MRI)

MRI will be obtained at study entry, following any TBI occuring during sanctioned practice or play, and at study exit.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Currently enrolled and active UF student athlete in Mens Football, Womens Soccer, or Womens Lacrosse. * Age 18-30

Exclusion criteria

* Contraindications to MRI, such as retained metal * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Fractional Anisotropy (FA)	Change in baseline up to 5 years.	Changes in FA values will assessed in the white matter of the brain at the time points noted.

Secondary

Measure	Time frame	Description
Neuropsychometric testing	Change in baseline up to 5 years.	Correlation of standard neuropsychometric testing will be compared with results of MRI.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026