Imaging of Atherosclerosis With 68Ga-MSA

Identification of Vascular Inflammatory Image Using a 68Ga-MSA(Gallium-68 Neomannosyl Human Serum Albumin) in Patients With Atherosclerotic Lesions

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01889693

Enrollment

Registered

2013-06-28

Start date

2012-08-31

Completion date

2013-08-31

Last updated

2013-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis, Noninvasive Imaging of Atherosclerosis

Keywords

positron emission tomography, macrophage, neomannosyl human serum albumin

Brief summary

Despite of intensive efforts, no specific ath¬erosclerosis-targeting agent labeled with positron emitter is not yet available. Fortunately, some scientists made the major advance in the field of clinical atherosclerosis molecular imaging by the metabolic PET reporter agent 18F(fluorine-18)-FDG(Fludeoxyglucose) applied to noninvasively image plaque macrophages in carotid arteries. However, coronary and cerebral arterial segments remain uninterpretable due to metabolic property of 18F-FDG. Applying the character of the terminal mannose residues of MSA binding with the mannose receptors of macrophages in atherosclerosis, we investigate whether 68Ga-MSA can be a novel agent for non-invasive molecular imaging of atherosclerotic lesion in PET.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* acute coronary syndrome(acute myocardial infarction, unstable angina) * chronic stable angina * control without coronary artery disease

Exclusion criteria

* pregnancy, allergy to albumin, chronic inflammatory disease

Design outcomes

Primary

Measure	Time frame
comparison of SUV(standard uptake unit) at atherosclerotic plaque of aorta and carotid arteries among 3 groups	1 day at the time of PET(positron emission tomogram) imaging

Secondary

Measure	Time frame	Description
side effect of PET imaging with 68Ga-MSA	with 7 days after PET imaging	any side effects including changes of biochemical values and vital signs

Countries

South Korea

Outcome results