Chronic Cough Caused by Gastroesophageal Reflux
Conditions
Keywords
Chronic cough, proton pump inhibitor, GERD, nonacid reflux,
Brief summary
Efficacy of proton pump inhibitor for chronic cough caused by gastroesophageal reflux; double-blind, placebo-controlled, randomized clinical trial
Interventions
DRUGHigh-dose PPI
:40mg, po(per oral) 2times.day, 8weeks
DRUGstandard PPI
: 40mg, po(per oral) 1times.day, 8weeks
DRUGplacebo
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
19 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
ages of 18 and 70 years had chronic cough of \>8 weeks in duration
Exclusion criteria
1\. abnormal chest X ray, PNS view 2. previous surgical or endoscopic antireflux procedure 3. previous aerodigestive malignancy or Barrett's oesophagus 4. current smokers or ex-smok-ers (defined as those who quit smoking \<3 months prior to study enrolment or those who have quit, but have a 20 pack year smoking history) 5. Malignancy History (lung cancer, esophageal cancer etc.) 6. upper respiratory infection within 8 weeks of study enrolment 7. currently using a PPI, H2 blocker, beta-blocker, angiotensin-converting enzyme inhibitor, corticosteroid, methylxanthine, inhaled beta-agonist, anti-inflammatory agent or anticholinesterase drug at time of enrolment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in LCQ score and cough VAS, comparing PPI-treated group to placebo | change in LCQ score after 4 weeks and 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| change in LCQ score and cough VAS, comparing PPI-treated group to placebo | change in cough VAS after 4weeks and 8 weeks |
Countries
South Korea
Outcome results
None listed