Lung Cancer
Conditions
Brief summary
This clinical trial studies computed tomography (CT) in diagnosing patients with lung cancer. Diagnostic procedures, such as CT, may help find and diagnose lung cancer.
Detailed description
PRIMARY OBJECTIVES: I. Conduct a prospective clinical imaging study to quantify the amount of inter- and intra-physician contouring variability on four dimensional (4D) CT, active breathing control (ABC) CT, free breathing CT, and free breathing and ABC cone beam (CB)CT. II. Quantify the magnitude and distribution of target and organ at risk volume variations between the different imaging modalities. III. Determine dosimetric changes related to contouring variations for tumor and normal tissue. OUTLINE: Patients undergo conventional free breathing CT, 4D CT, ABC CT, ABC CBCT, and free breathing CBCT before undergoing radiation therapy.
Interventions
PROCEDUREcomputed tomography
Undergo conventional free breathing CT
PROCEDURE4-dimensional computed tomography
Undergo 4D CT
PROCEDUREcone-beam computed tomography
Undergo ABC CBCT
Sponsors
Virginia Commonwealth University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Measurable disease on CT scan * Patients with lung cancer visible on CT who are scheduled to receive external beam radiation treatment will be eligible for this study * Patients must be able to perform ABC procedures
Exclusion criteria
* Patients requiring continuous supplemental oxygen due to the requirement of spirometry during all imaging studies * No vulnerable populations will be enrolled (prisoners, children, pregnant females or institutionalized individuals) * Women of childbearing potential will undergo a pregnancy test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of inter- and intra-physician contouring variability on 4D CT, ABC CT, free breathing CT, and free breathing and ABC CBCT | up to 1 week | A two sided t-test with 5% level of significance will be used. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Magnitude and distribution of target and organ at risk volume variations between the different imaging modalities | up to 1 week | A two sided t-test with 5% level of significance will be used. |
| Dosimetric changes related to contouring variations for tumor and normal tissue | up to 1 week | A two sided t-test with 5% level of significance will be used. |
Countries
United States
Outcome results
None listed