Subarachnoid Hemorrhage.
Conditions
Brief summary
Recently, a clinical trial showed that the use of lumbar drains compared to ventricular drain in patients suffering from subarachnoid hemorrhage resulted in less delayed ischemic neurological deficits but failed to show a clinical benefit after 6 months. The underlying assumption was, that the cerebrospinal fluid (CSF) obtained from lumbar drains has a higher concentration of blood than CSF from lumbar drains. The investigators decided to test this assumption. In this study, the investigators will randomize patients to either placement of a ventricular or a lumbar drain and analyze the CSF drainage on a daily basis.
Interventions
PROCEDURELumbar drain
PROCEDUREVentricular drain
Sponsors
Odense University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the neuro-ICU with aneurysmal subarachnoid hemorrhage * In need for CSF drainage based on clinical judgment
Exclusion criteria
* intraventricular clots * intraparenchymal clots causing midline shift * pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accumulated Hb and bilirubin in CSF drainage | From drain placement to removal, in average 10 days. |
Secondary
| Measure | Time frame |
|---|---|
| placement of a ventriculoperitoneal shunt | participants will be followed for the duration of hospital stay, in average 3 weeks |
| Lindegaard ratio (TCD) > 3 | the participants will be followed for the duration of hospital stay, in average 3 weeks |
| clinical signs of vasospasms | The participants will be followedd for the duration of hospital stay, in average 3 weeks |
Countries
Denmark
Outcome results
None listed