Auditory Verbal Hallucinations in Schizophrenia

Electromyography Study of Lip Muscles During Auditory Verbal Hallucinations Without Subvocalization in Patients With Schizophrenia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01886417

Acronym

HAV

Enrollment

Registered

2013-06-25

Start date

2009-10-31

Completion date

2015-03-31

Last updated

2015-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Brief summary

Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a relevant external stimulation. Some accounts of AVHs claim that a deficit in inner speech monitoring would cause the verbal thoughts of the patient to be perceived as external voices resulting in AVHs. In order to examine whether AVHs correspond to self-generated inner speech, the present study aims at collecting speech muscle activity during covert AVHs (without articulation), overt speech and rest. Surface electromyography (sEMG) is used on schizophrenia patients and control subjects to detect any speech muscle activity during AVH.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy controls: * must be more than 18 years and less than 60 years old * pre-inclusion medical examination * must have signed consent form * must be able to read stimuli on a screen Schizophrenia patients: * must be more than 18 years and less than 60 years old * pre-inclusion medical examination * must have signed consent form * must be able to read stimuli on a screen * diagnosed with a schizophrenia disorder according to DSM-IV TR (diagnostic and statistical of mental disorders) (PANSS item P3 greater than 4) * prior evaluation of the secondary effects of any medication via Barnes and AIMS scales * affiliated with the French social security * if under guardianship, must have additional consent form signed by guardian

Exclusion criteria

Healthy controls: * if aged less than 18 years or more than 60 years * diagnosed with any psychiatric disorder * with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.) * with auditory impairment * pregnant, parturient, breast-feeding Schizophrenia patients: * if aged less than 18 years or more than 60 years * significant secondary effects of antipsychotic medication, measured with the Barnes and AIMS scales * with a neurodegenerative disease * with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.) * with auditory impairment * pregnant, parturient, breast-feeding

Design outcomes

Primary

Measure	Time frame
Labial EMG activity during auditory verbal hallucination	up to 3 years

Countries

France

Outcome results