Observation of Neuromuscular Block
Conditions
Brief summary
This study aims to find appropriate dose of neostigmine which is possible to reverse rocuronium or cisatracurium till train of four (TOF) 0.9 within 10 minutes.
Interventions
DRUGInjection of neostigmine
At induction, we will inject rocuronium 0.6 mg/kg for rocuronium arms and cisatracurium 0.15 mg/kg for cisatracurium arms. During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, normal saline 5 ml will be injected in placebo arms. And neostigmine 10, 20, or 40 ㎍/kg will injected in each arms.
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 69 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologist Physical status classification 1 or 2 elective surgery under general anesthesia
Exclusion criteria
* BMI \>25 or \< 20 kg/m2 * Patients taking intercurrent medication * Glutamic Oxalacetate Transaminase or Glutamic Pyruvate Transaminase \> 40 IU/L, Cr \> 1.4 mg/dl
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| time to reverse from light muscle relaxation | time from TOF 0.5 to TOF 1.0 after injection of different doses of neostigmine | Primary outcome of this study is how long it takes time to reverse from TOF ratio 0.5 to 1.0 after injection of different doses of neostigmine at the TOF 0.5 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time to reverse from TOF ratio 0.5 to 0.9 | time from TOF 0.5 to TOF 0.9 after injection of different doses of neostigmine | Secondary outcome of this study is how long it takes time to reverse from TOF ratio 0.5 to 0.9 after injection of different doses of neostigmine at the TOF 0.5 |
Countries
South Korea
Outcome results
None listed