Inflammation, Nutritional Intervention, Obesity
Conditions
Brief summary
The study will quantitatively evaluate the systemic, postprandial inflammatory and metabolic response to the ingestion of three different meals in obese subjects. The administered meals will differ in the proportion of dairy products. Postprandial response will be monitored during 6 hours after meal consumption.
Interventions
OTHERconsumption of test meal based on dairy products
OTHERconsumption of high fat test meal without dairy products
OTHERconsumption of high fat test meal with dairy products
Sponsors
Insel Gruppe AG, University Hospital Bern
Agroscope Liebefeld-Posieux Research Station ALP
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
25 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* male * BMI ≥ 20 kg/m2 * age 25-55 y * informed consent
Exclusion criteria
* Physiological or psychological diseases * Allergies to food or intolerance to high-fat meal * Vegetarians * Chronic intake of drugs * Smokers * Diabetes mellitus Type I and II * Debilitating kidney diseases * Debilitating liver diseases * Clinically established coronary heart diseases * Ingestion of vitamins or dietary supplements during the course of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammation markers in blood plasma (IL-6, TNF-alpha) | 0,6h |
Secondary
| Measure | Time frame |
|---|---|
| Biomarkers in blood (serum insulin, plasma glucose, GLP-1, lipids) | 0,1,2,4,6h |
| Endotoxin in blood serum | 0,6h |
Other
| Measure | Time frame |
|---|---|
| Blood cell transcriptome | 0,2,4,6h |
| blood serum metabolome | 0,2,4,6h |
Countries
Switzerland
Outcome results
None listed