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Silent Ureteral Stone: Impact on Renal Function and Kidney Anatomy

The Impact of Silent Ureteral Stone on Renal Function and Kidney Anatomy: a Prospective Analysis

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01884870
Enrollment
25
Registered
2013-06-24
Start date
2012-11-30
Completion date
2015-08-31
Last updated
2015-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urinary Calculi

Keywords

Asymptomatic, ureteral, calculi, renal function, treatment

Brief summary

Ureteral stones may be silent in 5.3% of patients. The goal of this study was to prospectively evaluate the impact of a silent ureteral stone on renal function.

Detailed description

The prevalence of nephrolithiasis is increasing worldwide, reaching 5.2% in North America and 10.1% in Italy. The widespread use of computed tomography and ultrasonography have resulted in a greater detection rate of asymptomatic stones and, in part, might explain the trend. Clinically, kidney or ureteral stones range in severity from asymptomatic to presenting with complete renal failure. Therefore, it is not only the alarming incidence of urinary stone disease, but also the associated burden that makes this one of the most concerning conditions in public health. The situation becomes even more distressing when managing asymptomatic stones. Studies of the natural history of stones have revealed that only 20% of patients yearly actually become symptomatic from a new stone, and one half of those require surgical intervention at some point. The guidelines are well established for the treatment of symptomatic urolithiasis, and many investigators have extensively studied the management of silent kidney stones. Conversely, the same is not true for silent ureterolithiasis. The purpose of the present study is to report the investigators experience managing silent ureteral stones and to prospectively analyze their true influence on renal function.

Interventions

PROCEDURESurgical Treatment

Surgical Treatment - open, endoscopic or laparoscopic

Sponsors

University of Sao Paulo
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Silent ureteral stone: no subjective/objective symptoms related to the ureteral calculi. * Patient willing to participate in the study * Complete pre/post-operative work-up

Exclusion criteria

* Treatment outside our institution * No will to be a part of the study * Incomplete pre/post-operative work-up

Design outcomes

Primary

MeasureTime frameDescription
Ipsilateral Renal Function1 yearIpsilateral renal function determined by dimercaptosuccinic acid scintigraphy (DMSA) 12 months after surgery.

Secondary

MeasureTime frameDescription
Serum Creatinine level1 yearSerum Creatinine level
Estimated Creatinine Clearance1 yearEstimated Creatinine Clearance
Renal Anatomy assessed by Ultrasound1 yearRenal Anatomy assessed by Ultrasound

Countries

Brazil

Contacts

Primary ContactGiovanni S Marchini, MD
giovanni_marchini@yahoo.com.br55-11-98179-8186

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026