Burns, Neurotrophic Ulcers
Conditions
Keywords
damage to the skin, the skin equivalent, cell therapy
Brief summary
In Russia the treatment nonhealing skin defects often limited to surgical interventions, despite having developed modern methods of treatment of non-healing ulcers and other skin imperfections. During the many years of research we have developed a skin equivalent comprising living cells. During pilot trial showed that the skin equivalent provides healing skin defect within 1-4 weeks in 95% of patients.
Interventions
BIOLOGICALstudy of the efficacy of skin equivalent comprising living cells and skin biodegradable substrate for the treatment of skin lesions
Sponsors
Ural State Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* The presence of non-healing ulcer at least a month, an area of not less than 3 cm2 or smaller area of deep defects; * Availability of burns II or III level; * Epidermolysis bullosa; * Availability of post-burn scars * Defects in the skin after surgery
Exclusion criteria
* Acute and chronic diseases in the acute stage; * Autoimmune diseases of connective tissue (collagen); * Immunodeficiency states; * System of inflammatory diseases of the skin; * Conduct an aggressive corticosteroid therapy; * Acute coronary syndrome; * Acute disorders of cerebral circulation; * Availability of local inflammation in the acute stage; * Pregnancy; * Breast-feeding. * Positive results of the following tests: Anti-HIV-1 and -2, HIV-1Ag, anti-HTL VI and-II, anti-HbcorAg, HBs-Ag, anti-HCV, anti-CMV, anti-Toxoplasma gondii, RW, Neisseria gonorrheae, Chlamydia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficiency | six weeks |
Countries
Russia
Contacts
Primary ContactArteom V Korotkov
Outcome results
None listed