Prediabetes
Conditions
Keywords
prediabetes, physical inactivity, sedentary, standing
Brief summary
The study is a crossover, pilot trial examining the acute effects of standing on blood sugar in prediabetic, working adults. Participants will complete oral glucose tolerance testing, once while sitting and once while standing. They will also wear a continuous blood sugar monitor once while sitting at their desk for a week and once while using their desk as a sit-stand desk with a goal of standing intermittently for at least half of the work day. Physical activity levels will be measured with an accelerometer. The primary study hypothesis is that blood sugar will differ between the sitting and standing conditions for each of the tests performed.
Interventions
OTHERSitting OGTT
OTHERStanding OGTT
OTHERSitting CGM
OTHERStanding CGM
Sponsors
Mayo Clinic
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Fasting blood glucose \>100 mg/dl * Employed full-time working at least 35 hours/week * Able to safely begin a light physical activity program
Exclusion criteria
* Heart disease * Renal disease * Peripheral neuropathy * Retinopathy * PAD * Lower limb amputation * pregnancy * active substance abuse * current smoker * psychiatric disorder * severe visual impairment * immune-compromised individuals, * enrollment in a physical activity study * use of insulin or an insulin pump
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood sugar area under the curve | 2 hours | The area under the curve following the 2 hour blood sugar tests. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Accelerometer counts | 4 hours and 2 5 day periods | Accelerometer counts in the 4 testing conditions. |
Countries
United States
Outcome results
None listed