Fetuin A in Hashimoto Thyroiditis

Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01884649

Enrollment

Registered

2013-06-24

Start date

2012-05-31

Completion date

2012-10-31

Last updated

2013-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hashimoto Thyroiditis

Keywords

Acute phase reactant, fetuin A, Hashimoto thyroiditis

Brief summary

Fetuin-A levels are reported to be low as a negative acute phase reactant in systemical inflammatory situations. Hashimoto thyroiditis is characterized with inflammation. In this study, we hypothesised that the serum fetuin A levels could be found to be low due to inflammation in patients with Hashimoto thyroiditis

Detailed description

Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the eligibility criteria will be included in the study. Approval of the local ethics committee and informed consent of the participants will be received for the study. The study is conducted in accordance with the Declaration of Helsinki. Demographic characteristics, concomitant diseases, smoking and alcohol drinking habits, concomitant medication usage, anthropometric and biochemistry data of the eligible patients will be recorded. Patient group will consist of patients with newly diagnosed Hashimoto thyroiditis and the control group will consist of healthy volunteers. Groups will be compared according to their demographic, an¬thropometric and biochemistry data and serum fetuin-A levels. In order to detect the relationship between the serum fetuin-A levels and clinical features, correlation analyses will be done.

Interventions

None listed

Study design

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients newly diagnosed with Hashimoto thyroiditis

Exclusion criteria

* Acute infection * Acute or chronic inflammatory disease * Anti-inflammatory treatment (non-steroidal anti-inflammatory, corticosteroids etc.) * Hypoxic situations (chronic obstructive pulmonary disease etc.) * Severe heart, kidney and liver disease * Pregnancy * Endocrine disorders * Malignancy * Usage of drug that affects thyroid hormone levels

Design outcomes

Primary

Measure	Time frame
Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects	1 day (The blood samples were obtained on the same day participants arrived to outpatient clinics.)

Outcome results