Postoperative Complications
Conditions
Keywords
remifentanil, isolated systolic hypertension, morbidity, epidural combined general anesthesia
Brief summary
In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits of stress block, less depression of breath. however, the epidural technique often causes more drop of blood pressure, especially in dehydrated patients. The investigators designed the trial to see if the benefit weigh out the potential risk of epidural in isolated hypertensive patients.
Interventions
None listed
Sponsors
Peking University First Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
\- adults aged 50-70 with isolated systolic hypertension .
Exclusion criteria
* age \< 50 yr, ASA grade IV, severe cardiac or pulmonary insufficiency (FEV1 \< 1 litre) , malignant hypertension, psychiatric illness (intake of psychiatric medication other than selective serotonin re-uptake inhibitors), diastolic blood pressure more than 110 mmHg. emergency surgery, coagulopathy, significant renal and hepatic dysfunction (creatinine \> 50% or liver enzymes \> 50% upper limit of normal values)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Length of postoperative hospital stay | 5 weeks | days |
| cardiovascular morbidity | 2 weeks | case |
| respiratory morbidity | 2 weeks | case |
| postoperative renal failure | 2 weeks | case |
Countries
China
Outcome results
None listed