Heart Failure
Conditions
Brief summary
The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.
Interventions
OTHERAerobic Exercise Training
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
University of Sao Paulo General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients with systolic heart failure; * New York Heart Association (NYHA) class II-III; * Left ventricular ejection fraction less than 40%; * Peak Oxygen Consumption less than 20 ml/Kg/min; * Stable Clinical Status.
Exclusion criteria
* Chronic Obstructive Pulmonary Disease; * Neuromuscular Diseases; * Orthopedic Diseases; * Neurologic Diseases; * Neoplastic Diseases; * Recent myocardial infarction or cardiac surgery (less than 6 months); * Unstable angina pectoris; * Atrial Fibrillation; * Pacemakers users; * Changing medication or hospital admission.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Autonomic Control | 4 months | Mechanoreceptors were activated by passive exercise and metaboreceptors by post-exercise circulatory arrest |
| Muscular Evaluation | 4 months | Muscular evaluation will be done by muscle gene expression |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional Capacity | 4 months | Functional Capacity will be determined by cardiopulmonary exercise testing |
| Muscle Blood Flow | 4 months | Forearm blood flow will be assessed by venous occlusion plethysmography |
| Blood Pressure | 4 months | Blood pressure will be monitored non-invasively |
Countries
Brazil
Outcome results
None listed