Acute Vascular Response To Meals Varying In Glycemic Index And Glycemic Load

Variability of Acute Response to Equicaloric Test Meals Varying in Glycemic Index and Glycemic Load on Postprandial Glycemia, Arterial Stiffness and Blood Pressure in Healthy Adults

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01883700

Acronym

HILO

Enrollment

Registered

2013-06-21

Start date

2010-08-31

Completion date

2013-09-30

Last updated

2013-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Healthy, Glycemic Index, Glycemic Load, Blood Glucose, Arterial Stiffness

Brief summary

This study examines the effects of carbohydrate type (high- or low-Glycemic Index (GI)) and amount (high- or low-Glycemic Load (GL)) have on blood glucose levels, blood pressure and arterial stiffness in healthy individuals. It will also determine whether subjective ratings such as test meal palatability and hunger are related to changes in blood glucose. The investigators hypothesize that: (1) High-GI meals, regardless of GL, will increase arterial stiffness; low-GI meals, regardless of GL, will have a neutral or lowering effect on arterial stiffness (augmentation index). (2) High-GI meals, regardless of GL, will have an elevating effect on both central and peripheral blood pressures. (3) The incremental area under the curve for blood glucose will show most significant differences between high-GI, high-GL and low-GI, low-GL meals at 30 and 90 min.

Interventions

OTHERBoiled Pasta

OTHERBoiled Chickpeas with Oil

OTHERInstant Mashed Potatoes

OTHERInstant Mashed Potatoes with Egg Whites

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy * age 18 - 75 years * BMI 18 - 25 kg/m2 * brachial systolic blood pressure \< 140 mmHg * brachial diastolic blood pressure \< 90 mmHg

Exclusion criteria

* primary hypertension * diabetes * allergy or sensitivity to any foods to be used in the study * gastrointestinal disorders * chronic kidney disease * liver disease * hepatitis * estrogen-sensitive cancer * heavy alcohol use * sleep apnea * bleeding disorders * planned surgery (within time frame of study) * angina * Congestive Heart Failure * coronary revascularization * peripheral vascular disease and/or coronary/cerebrovascular events within the previous 6 months * positive HIV diagnosis * prescription of anti-depressants, anti-hypertensives, anti-coagulant medications, diuretics, sympathomimetics, herbal therapies, vitamin or K supplementation, medication affecting NO synthesis * chronic use or prescription of NSAIDs * women of childbearing potential must not be pregnant or breastfeeding

Design outcomes

Primary

Measure	Time frame
To measure postprandial changes in augmentation index (AIx) to determine the acute effect of high- and low-GI and high- and low-GL meals on arterial stiffness.	4 separate mornings, measurements taken at baseline and at 60, 120, 180 and 240 minutes

Secondary

Measure	Time frame
To determine the acute effect of high- and low-GI and high- and low- GL meals on central and peripheral blood pressure	4 separate mornings, measurements taken at baseline, 60, 120, 180 and 240 minutes.

Other

Measure	Time frame
To determine whether the effects of high- and low-GI and high- and low-GL meals on postprandial glycemia are correlation with arterial stiffness, central and peripheral blood pressure.	4 separate mornings, measurements taken at baseline 15, 30, 45, 60, 90, 120, 180 and 240 minutes

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026