Normal Pregnancies
Conditions
Brief summary
Genetic and environmental factors are believed to play a major role in intrauterine growth and intrauterine programming. We intend to study genetic factors such as Telomere homeostasis, senescence, genomic instability and the presence of Genomic copy number variations in placental tissue from pregnancies complicated with Intrauterine growth restriction(IUGR), Gestational and pre gestational Diabetes, placentas from IVF pregnancies and from normal pregnancies. We also intend to assess these factors in cord blood and maternal blood.
Detailed description
Based on the previous data from our group as well as other laboratories, we postulate that there is a correlation between impaired telomere homeostasis, senescence genomic instability and intra-uterine programming in placentas and in fetuses exposed to suboptimal intrauterine conditions such as hypoxia or hyperglycemia. Improved understanding of the mechanisms that produce the genomic changes in IUGR placentas and their influence on later risks of developing the metabolic syndrome should provide basis for future research that might lead into improved outcome of IUGR fetuses.
Interventions
None listed
Sponsors
Meir Medical Center
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* A diagnosis of Intrauterine growth restriction * A diagnosis of Gestational diabetes * A diagnosis of pre gestational Diabetes * IVF pregnancy
Exclusion criteria
* chorioamnionitis * meconium stained amniotic fluid * A request of the patient for Cord blood retrieval for preservation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of Copy Number Variations | 10 yeras |
Secondary
| Measure | Time frame |
|---|---|
| Telomere length | 10 years |
| Number of copies of mitochondrial DNA | 10 years |
Countries
Israel
Contacts
Primary ContactTal Biron Shental, MD
Backup ContactRivka Sukenik-Halevy, MD
Outcome results
None listed