Tracheostomized Patients
Conditions
Keywords
Nebulization aerosol nebulizer tracheostomy
Brief summary
To compare lung deposition of amikacin in two settings: spontaneously breathing through a tracheostomy cannula and through the mouth.
Interventions
OTHERNebulization through the tracheostomy
Each subject received two nebulization sessions under spontaneous breathing in a sitting position. The first session was performed prior to tracheostomy removal. During the first nebulization, subjects inhaled the aerosol through the tracheostomy, cuff inflated and inner cannula removed.
OTHERNebulization through the mouth
Each subject received two nebulization sessions under spontaneous breathing in a sitting position. The second nebulization was performed when the tracheostome was totally scarred. During the second nebulization, subjects inhaled the aerosol a mouth piece and wore a nose clip.
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patient who were likely to require an elective tracheostomy surgery as part as their head and neck surgery
Exclusion criteria
* Allergy to Aminoglycosides * Patients who received Aminoglycosides treatment less than one month prior the surgery * Pectoralis major flap reconstruction * Latissimus dorsi flap reconstruction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amikacin urinary drug concentration | At each micturition during 24 hours |
Countries
Belgium
Outcome results
None listed