Evaluation of Immune Signaling Networks in Healthy Human Volunteers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01882582

Enrollment

Registered

2013-06-20

Start date

2012-08-31

Completion date

2013-07-31

Last updated

2016-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal Immune Cell Function

Brief summary

The purpose of this study is to better understand whether and to what extent the activity of immune cells in blood varies over time under normal conditions as assessed in healthy subjects. Results of this study will provide the foundation for helping us evaluate changes in immune cell activities in response to surgery and drugs used in anesthesia. The overall purpose of our research is to understand immune health in the context of anesthesia and surgery.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

1. Age 18-50 2. Good general health

Exclusion criteria

1. Recent cold or flu 2. Chronic use of medications affecting the immune system 3. Chronic illness 4. Smoking habit 5. History of drug abuse 6. Current recreational drug use

Design outcomes

Primary

Measure	Time frame	Description
Numerical and functional changes of circulating immune cells over time in healthy individuals	Day 1, Day 2, Day 7, Day 28	This is an exploratory study. Numerical and functional (phosphorylation of signaling molecules and transcription factors) behavior of all circulating immune cells will be captured. Blood specimens collected at referenced time points will be analyzed with mass cytometry.

Countries

United States

Outcome results