Study of Opioid Immunosuppressive Effects

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01881802

Enrollment

Registered

2013-06-20

Start date

2013-03-31

Completion date

Unknown

Last updated

2013-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid Abuse or Dependence

Keywords

Opioid drug Abuse, Morphine, Immune Function

Brief summary

This trial aims to investigate the effects of opioid-inducing immune suppression on opioid drug abused patients. The methods of the investigators research mainly includes the expression of morphine-related miRNAs in peripheral blood mononuclear cells and cytokine in plasma.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Inclusion criteria

* subjects were excluded if they had a chronic systemic illness (cardiac, renal, pulmonary, hepatic, endocrine, metabolic, or autoimmune disorders) or * a major psychiatric disorder or * if they were abusing substances other than heroin (as determined by urine drug test result). For women, pregnancy was also a reason for exclusion.

Exclusion criteria

* Control subjects with no history of drug or alcohol abuse were also excluded if they had * major medical or psychiatric disorders

Design outcomes

Primary

Measure	Time frame
real-time quantitative polymerase chain reaction	up to 2 months

Secondary

Measure	Time frame
enzyme-linked immuno sorbent assay	up to 2 months

Outcome results