ICU Patients, In State of Coma (Define by Glasgow ≤ 8), No Antibiotic Treatment, Under Mechanical Ventilation
Conditions
Keywords
Aspiration pneumonia, Coma, Mechanical ventilation
Brief summary
Inhalation is a common condition in patients with impaired their awareness requiring protection of the upper airway by endotracheal intubation. This inhalation may lead to chemical pneumonitis and/or bacterial pneumonia. Only the latter requires the administration of antibiotics. Patients developing such a bacterial pneumonia, has a mortality, duration of mechanical ventilation and length of ICU stay increased. However, the proportion of patients with such bacterial pneumonia, bacterial ecology and morbidity that are little known. The aim of this study is to determine the frequency of bacterial pneumonia in patients admitted to the ICU for coma and treated with mechanical ventilation
Interventions
None listed
Sponsors
Centre Hospitalier Departemental Vendee
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Altered consciousness defined by a Glasgow Coma Scale score less than or equal to 8 before protection of the upper airway by endotracheal intubation * Patient under mechanical ventilation
Exclusion criteria
* Patient with pre-existing impairment of laryngeal function in Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, laryngeal cancer, radiotherapy laryngeal * Patient under guardianship * Inpatient without consent * Pregnant woman * Patient previously treated with antibiotics for more than 24 hours at the time of ICU admission * Patient with infection at ICU admission which justified probabilist antibiotic treatment * Lack of social security * Refusal of the patient or their next of kind
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determine the frequency of bacterial pneumonia in patients admitted to the ICU for coma and treated with mechanical ventilation | ICU Discharge | Participants will be followed for the duration of ICU stay, an expected average of 4 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantify the use of antibiotics during the ICU stay for patients admitted to the ICU for coma and treated with mechanical ventilation | ICU Discharge | Participants will be followed for the duration of ICU stay, an expected average of 4 days |
| Description of the bacterial flora identified in respiratory specimens. | ICU Discharge | Participants will be followed for the duration of ICU stay, an expected average of 4 days |
| Identification of predictive factors for development of bacterial pneumonia | ICU Discharge | Participants will be followed for the duration of ICU stay, an expected average of 4 days |
Countries
France
Outcome results
None listed