Intubation, Intratracheal
Conditions
Brief summary
To find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in normotensive and hypertensive patients
Detailed description
It is known that anesthetic agents can influence the QTc. In addition, tracheal intubation during induction can stimulates sympathetic activity, which, as a results, prolong the QTc interval. Therefore, the aim of study is to find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in normotensive and hypertensive patients.
Interventions
DRUGRemifentanil
The effect site concentration of remifentanil
Sponsors
Severance Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥ 50 years ASA class I-II female who received surgery with endotracheal intubation
Exclusion criteria
* emergency surgery electrocardiography abnormality diabetes mellitus end stage renal disease moderate to severe cardiac disease moderate to severe liver dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect site concentration of remifentanil for preventing QTc interval prolongation | 2 min |
Countries
South Korea
Outcome results
None listed