Breast Cancer
Conditions
Keywords
breast cancer, screening, mammography, ultrasound
Brief summary
Early detection of breast cancer through screening has been a common practice in the United States and several European countries for decades.It is effective in reducing the mortality of breast cancer and improving the postoperative quality of life of patients. Mammography has been the standard imaging method for the screening, and in recent years, a supplemental ultrasound exam is also recommended.A prospective, multi-center, randomized trial is needed to define an optimal screening strategy that suits Chinese women and the socioeconomics of China.
Interventions
OTHERmammography
participants were screened by mammography alone every year
OTHERultrasound
participants were screened by ultrasound alone every year
Participants were screened by both mammography and ultrasound every year
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Written informed consent； * residence from community or working units
Exclusion criteria
* pregnancy； * lactation； * known metastatic cancer； * signs or symptoms of breast disease； * presence of breast implants, breast surgery within prior 12 months； * had mammography or ultrasound exam within prior 12 months * males.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| screening yield | 3 years | Sensitivities, specificities, positive predictive values, and negative predictive values |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cost-effectiveness | 3 years | cost of each screening modility to detect one cancer |
Countries
China
Outcome results
None listed