Genetic Analysis of Chronic Central Serous Chorioretinopathy Masquerading as Neovascular AMD

Evaluation of Genetic Variants in Patients With Type 1 Neovascularization (Sub-retinal Pigment Epithelium Neovascularization) Who Lack Typical Findings of Age Related Macular Degeneration (AMD) But Present With Findings More Consistent With Long-standing Central Serous Chorioretinopathy (CSC).

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01880788

Enrollment

152

Registered

2013-06-19

Start date

2012-11-30

Completion date

2015-08-31

Last updated

2015-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age Related Macular Degeneration, Central Serous Chorioretinopathy, Choroidal Neovascularization

Keywords

Age Related Macular Degeneration, Choroidal Neovascularization, Central Serous Chorioretinopathy

Brief summary

The study will be designed as a case control evaluation to compare the genetic profiles of three groups of patients categorized according to diagnosis. Group 1 - CNV secondary to CSC Group 2 - CSC without CNV Group 3 - CNV secondary to advanced AMD.

Detailed description

To determine if patients presenting with type 1 neovascularization believed to be secondary to CSC are genetically distinct from typical CSC patients without neovascularization or patients presenting with choroidal neovascularization (CNV) secondary to advanced AMD. Disease associated markers detecting variants in ARMS 2, Complement Factor H (CFH) Complement component 3 (C3), Complement component 2 (C2) , Factor B (FB), VEGFA or other genetic polymorphisms associated with CNV will be evaluated to determine if the CSC neovascular group is genetically distinct from the CSC group without neovascularization or the advanced AMD group.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

* Caucasian * 30 years and older (CSC) * 50 years and older (Advanced AMD) * Genders Eligible for Study: Both * Completed Consent form * Diagnosis of choroidal neovascularization in at least one eye

Exclusion criteria

* Patient age less than 30 years (CSC). * Patient age less than 50 years (AMD). * Presence of retinal disease involving the photoreceptors and/or outer retinal layers other than AMD and CSC such as high myopia, retinal dystrophies, retinal vein occlusion, diabetic retinopathy and uveitis or similar outer retinal diseases which have been present prior to the age of 30. * Opacities of the ocular media, limitations of pupillary dilation or other problems sufficient to preclude adequate fundus photography. * Missing informed consent * Previous sample donation under this protocol

Design outcomes

Primary

Measure	Time frame	Description
Total genetic burden	Baseline assessment	The identification of individual genetic markers or a quantitative measure of total genetic burden associated with CNV secondary to CSC vs. CSC vs. CNV secondary to advanced AMD as meaured by the commercially available RetnaGene AMD assay.

Countries

United States

Outcome results