Cognitive Performance (Focus)
Conditions
Keywords
Memory, Attention
Brief summary
The study will explore the effects of a 6-week phospholipid drink intervention on the cognitive performance and physiological and subjective stress parameters of males following a repeated psychosocial/physical stressor.
Detailed description
The study conforms to a randomised, double-blind, placebo controlled, parallel groups design examining cognitive performance and physiological/subjective stress responses after a psychosocial/physical stressor before and after a six week daily intake of an phospholipid containing drink vs. placebo. The study will examine: Cognitive performance following acute stress prior to, and following 6-weeks intake of a phospholipid containing drink or a placebo analogue. Physiological and subjective stress responses following acute stress prior to, and following 6-weeks intake of a phospholipid containing drink or a placebo analogue
Interventions
DIETARY_SUPPLEMENTPhospholipid drink
Participant in an intervention parallel group will consume a drink with added phospholipids
DIETARY_SUPPLEMENTPlacebo milk drink
Participant in an intervention parallel group will consume a drink without added phospholipids
Sponsors
Arla Foods
University of Leeds
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Male ≥18 years old * Healthy (self-report health questionnaire) * BMI \<30 kg/m² * Free from medication (prescribed and 'over-the-counter')
Exclusion criteria
* Current psychological affective/mood disorders * Self-reported physical disorder/disease (significant cardiovascular, autoimmune, endocrine, gastrointestinal or neurological conditions, chronic pain, or sleep disorders) * High chronic stress * Smokers * Recreational drug use (within the last month) * Night shift work * Hypertension (resting blood pressure exceeding 160/95 mmHg) * Skin conditions (e.g. eczema) on hands * Food allergies * Participation in a clinical study within a month prior to screening or during participation * Participation in any of our previous stress induction studies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive performance change from baseline | Week 1 (baseline) and week 6 | Performance on a cognitive test battery at baseline will be compared to performance at week 6 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Salivary cortisol change from baseline | Week 1 (baseline) and week 6 | Salivettes will be used to collect salivary cortisol response across exposure to a laboratory stress protocol on two occasions separated by 6 weeks |
| Blood pressure (systolic/diastolic) change from baseline | Week 1 (baseline) and week 6 | An ambulatory blood pressure monitor will be used to collect blood pressure response profiles across exposure to a laboratory stress protocol on two occasions separated by 6 weeks |
| Heart rate change from baseline | Week 1 (baseline) and 6 weeks | An ambulatory blood pressure monitor will be used to collect heart rate response profiles across exposure to a laboratory stress protocol on two occasions separated by 6 weeks |
| Subjective stress change from baseline | Week 1 (baseline) and 6 weeks | The Stress and Arousal Checklist (Mackay, 1978)will be used to collect subjective stress response profiles across exposure to a laboratory stress protocol on two occasions separated by 6 weeks |
| Subjective mood change from baseline | Week 1 (baseline) and 6 weeks | The Profile of Mood States (Mc Nair et al., 1971)will be used to collect subjective mood response profiles across exposure to a laboratory stress protocol on two occasions separated by 6 weeks |
Countries
United Kingdom
Outcome results
None listed