Post-operative Neurosurgery
Conditions
Keywords
Aerosol, Lung deposition, Mechanical ventilation
Brief summary
Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition. The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.
Interventions
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Invasive mechanical ventilation * Healthy lungs
Exclusion criteria
* Change of ventilation mode during nebulization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary deposition | Immediately after nebulization by imaging assessment, an expected average of 30 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Penetration index | Immediately after nebulization by imaging assessment, an expected average of 30 minutes |
| Mechanical ventilation settings | During nebulisation time, an expected average of 15 minutes |
| Lung function | Preoperative assessment, the day before inclusion |
Countries
Belgium
Outcome results
None listed