Insulin Resistance
Conditions
Keywords
insulin resistance, exercise, continuous glucose monitoring, blood flow, endothelial function
Brief summary
The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining \>10,000 steps/day) can restore the detrimental effects on blood flow following a meal.
Detailed description
Herein, we tested the hypothesis that an acute reduction in daily activity (from \>10,000 to \<5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes.
Interventions
BEHAVIORALExercise
short period of inactivity (5 days) followed by a return to physical activity (1 day)
Sponsors
University of Kansas Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI: less than 30 kg/m2 * Physically active: exercise greater than 60mins per week
Exclusion criteria
* smoking * type 2 diabetes * Underlying conditions that limit ability to exercise safely * Recent weight gain or loss(\> 5% of body weight in 3 months) * Recent (\< 3 mo) changes in medication use or dose * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of Physical Inactivity on Post Prandial Blood Flow | 10 days | There was a pre-measurement period of 3 days, then 5 days of inactivity, followed by 1.5-2 days of return to activity. A 10 day time frame overall. Blood flow measured by Doppler ultrasound during an oral glucose tolerance test before and after 5 days of inactivity. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Exercise 5 days of inactivity followed by a 1 day return to physical activity
Exercise: short period of inactivity (5 days) followed by a return to physical activity (1 day) | 13 |
| Total | 13 |
Baseline characteristics
| Characteristic | Exercise |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 13 Participants |
| Age, Continuous | 24 years STANDARD_DEVIATION 3 |
| Region of Enrollment United States | 13 participants |
| Sex: Female, Male Female | 0 Participants |
| Sex: Female, Male Male | 13 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 13 |
| serious Total, serious adverse events | 0 / 13 |
Outcome results
Primary
Effects of Physical Inactivity on Post Prandial Blood Flow
There was a pre-measurement period of 3 days, then 5 days of inactivity, followed by 1.5-2 days of return to activity. A 10 day time frame overall. Blood flow measured by Doppler ultrasound during an oral glucose tolerance test before and after 5 days of inactivity.
Time frame: 10 days
Population: healthy, young, active men
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Exercise | Effects of Physical Inactivity on Post Prandial Blood Flow | 0 percentage of change in blood flow | Standard Deviation 3 |