The Effect of Obesity on Oral Peri-implant Health - A Cross-Sectional Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01878071

Enrollment

Registered

2013-06-14

Start date

2012-06-30

Completion date

Unknown

Last updated

2014-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Peri-implant Inflammation, Peri-implantitis

Brief summary

In recent years, greater emphasis has been placed on the link between oral and systemic health. Obesity, a growing medical problem worldwide, has been associated with multiple chronic inflammatory diseases such as diabetes mellitus and cardiovascular disease. With respect to the effect of obesity on periodontal health, it has been shown that obese subjects exhibit higher inflammation around natural teeth and are at increased risk of tooth loss than individuals with normal weight. Peri-implantitis, an inflammatory condition of bacterial origin that occurs around oral implants and resembles periodontal disease, has become a serious concern for the dental profession given its increasing prevalence and challenging treatment. There is also strong evidence that individuals with a history of periodontitis are also at risk for peri-implantitis. However, knowledge about the pathogenesis and treatment of peri-implantitis is scarce. Hence, it is extremely important to understand the implications of excessive body fat on peri-implant health. Based on the current understanding on the effect of obesity on systemic and local inflammation around natural teeth, the investigators hypothesize that obesity will have a significant impact on peri-implant health by inducing an increased inflammatory response as measured by clinical as well as molecular markers of inflammation.

Interventions

None listed

Study design

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Adults (18 years or older) * Currently non-smokers * Subjects in maintenance care with adequate dental plaque control (\<20% plaque index according to O'Leary et al. 1972) * Subjects with at least one rough surface titanium oral implant in function for at least 6 months.

Exclusion criteria

* Edentulous subjects or subjects presenting with blade-type implants and/or implants with smooth surface. * Pregnant or nursing women * Subjects who have taken medications that are known to alter the oral inflammatory status, such as antibiotics and anti-inflammatory agents, for 3 months prior to the study. * Subjects with a history of aggressive periodontitis (As defined by the American Academy of Periodontology).

Design outcomes

Primary

Measure	Time frame
Degree of peri-implant inflammation	Single time point - during their single visit (day one)

Countries

United States

Outcome results