Attention Deficit Disorder With Hyperactivity, Bipolar Disorder, Personality Disorder, Schizophrenia, Substance Use Disorder
Conditions
Keywords
Substance Use Disorder, Attention Deficit Disorder With Hyperactivity, Schizophrenia, Bipolar disorder, Personality disorder
Brief summary
The purpose of this study is to study the efficacy and security of noninvasive brain stimulation as a new approach for patients with Substance Use Disorders (SUDs) plus other psychiatric conditions like ADHD, Schizophrenia, Bipolar disorder, etc.
Detailed description
Background: There is an intimate relationship between addictive behaviors and other mental disorders, proven by clinical practice and many epidemiological studies, genetic and neuroscience. This gives risk to the diagnosis of Dual Pathology: an addiction and another mental disorder. Functional neuroimaging studies have shown that anterior cingulate cortex is associated with substance´s dependence and craving. Transcranial random noise stimulation (tRNS) stimulates parts of the brain and can change it´s activity. Researchers are interested in reduce cravings for substance dependence on patients with Dual Pathology using tRNS in anterior cingulate cortex. Aims: To determine whether tRNS in anterior cingulate cortex can reduce craving over Dual Pathology patients.
Interventions
Random Noise Stimulation between 100 and 500 Hz and 400-500 microAmperes are applied over head in particular areas
Sponsors
Spanish Foundation for Neurometrics Development
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* \> 18 years old and less than 60 years * Best-practice diagnosed Dual Pathology * Diagnosed since at least two years prior to enrollment. * Abuse more than 2 Substances ExclusionC riteria: * Serious visual and hearing loss * Brain injury following cranial trauma * Other neurological disorders like Parkinson, ME, headache, etc. * Birth trauma * Mental retardation * Pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AMEN Questionnarie | Following patients during 3 months after Brain noninvasive estimulation | 100 Items Questionnarie subdivided in 5 subscales: basal ganglia, cingulate cortez, temporal cortex, prefrontal cortex and limbic system |
| Emotional Visual Event Related Potentials | Following patients during 3 months after Brain noninvasive estimulation | Emotional Visual Event Related Potentials responses (time courses and topographies) and ICA components related with them, identified by Mitsar 201M EEG Amplifier using EEGLab software \[ Time Frame: brainwaves patterns following an array of visual stimuli (human faces) during a 22 min. examination \] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CAGE Adapted to Include Drugs (CAGE-AID) | Following 3 months after tRNS brain stimulation | The CAGE-AID is a sensitive screen for alcohol and drug problems. |
Countries
Spain
Outcome results
None listed