Evaluating Pain and Discomfort Associated With Cervical Punch Biopsy

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01876225

Enrollment

Registered

2013-06-12

Start date

2013-06-30

Completion date

2016-06-30

Last updated

2014-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety, Pain

Keywords

cervical biopsy, forced cough, pain, VAS scale

Brief summary

The use of forced coughing during cervical punch biopsy may reduce pain & discomfort associated with the procedure.

Detailed description

Pain and anxiety are associated with many medical procedures performed in ambulatory setting. Colposcopically guided punch biopsies are a standard procedure performed in women with abnormal cervical cytology, as a part of the diagnosis and treatment selection. Coughing is thought to provide a distraction and to cause a momentarily increase in blood pressure, reducing pain perception. Therefore, the present study is designed to compare pain associated with cervical punch biopsy and the effect of forced coughing on pain and pain perception.

Interventions

BEHAVIORALForced coughing during cervical punch biopsy

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

\- Women undergoing cervical punch biopsy

Exclusion criteria

* Women under 18 years old * Women currently taking prescription pain medications * Women who consumed pain medication up to 2 hours prior to the scheduled biopsy. * Women who refuse to take part in the study

Design outcomes

Primary

Measure	Time frame	Description
The pain associated with cervical biopsy	10 minutes	Evaluating pain during cervical punch biopsy using VAS 0-10 scale.

Secondary

Measure	Time frame	Description
Length of cervical punch biopsy with and without cough intervention	10 minutes	Measurement of procedure length in minutes

Other

Measure	Time frame	Description
Number of biopsies taken in a single session	12 minutes	During the examination, 1 to 3 cervical punch biopsies will be taken, according to colposcopic cervical appearance.

Countries

Israel

Contacts

Primary ContactEfraim siegler, MD

hfefraimsi@clalit.org.il972-4-8568486

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026