Endocrine System Diseases
Conditions
Keywords
glucagon-like peptide-1, peptide tyrosine tyrosine, ghrelin, stomach, small intestine, gastric emptying
Brief summary
The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.
Interventions
DIETARY_SUPPLEMENTPlacebo
DIETARY_SUPPLEMENTGlucose 25g
DIETARY_SUPPLEMENTGlucose 10g
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of \> 30 * Normal eating habits * Age 18-40 years * Stable body weight for at least three months
Exclusion criteria
* Smoking * Substance abuse * Regular intake of medications (except for oral contraceptives) * Medical or psychiatric illness * Any abnormality detected during the screening procedure * history of gastrointestinal disorders * food allergies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of different oral glucose loads on secretion of satiation hormones | 240min. | Plasma concentrations of glucose, insulin, glucagon, ghrelin, GLP-1, PYY and CCK are measured |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of different oral glucose loads on gastric emptying | 240min. | measured by C13 breath test |
Countries
Switzerland
Outcome results
None listed