Effect of Vitis Vinifera Extract on Oxidative Stress, Inflamatory Biomarkers and Hormones in High Trained Subjects

Effect of Vitis Vinifera Extract on Oxidative Stress, Inflammatory Biomarkers and Hormones in High Trained Subjects After Resting and Intensive Physical Activity.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01875497

Enrollment

Registered

2013-06-11

Start date

2013-01-31

Completion date

2015-12-31

Last updated

2013-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Athletic Injuries

Keywords

athletes, polyphenols, nutrition, oxidative stress

Brief summary

There is evidence that intense physical activity has a potential effect on thrombotic events due to catecholamine release. The hormones leptin and adiponectin have been used as markers of cardiovascular risk, but they are few and contradictory studies that relate physical training intensity and duration of high plasma concentrations of these hormones. The use of antioxidants, such as proanthocyanidins present in grapes, may help in reducing the undesirable effects of intense training.

Detailed description

Fifty four Brazilian healthy military without hyperglycemia, diabetes mellitus and endocrine disease were enrolled in this study. All subjects were high physically military trained. The Ethical Committee of the Universidade do Estado do Rio de Janeiro in Brazil (COEP008/2011) approved the study protocol. Informed consent was obtained from each subject after explanation of purpose and risks of all procedures used.

Interventions

DIETARY_SUPPLEMENTgrape fruit (vitis vinifera) extract in capsule with 205 mg

Before the exercise the indivuduals intake only one capsule of the grape fruit extract with 205 mg. This dosage is free of contraindications according to others studies.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy physically active men

Exclusion criteria

* Diabetes, hypertension, obesity subjects, drug use

Design outcomes

Primary

Measure	Time frame
Evaluate the changes of oxidative stress, microcirculation parameters, inflammation biomarkers and plasma adipokines in vitis vinifera extract supplemented and placebo subject before and after high intense training	This study will last 24 months (2013-2015)

Secondary

Measure	Time frame
Differences between body composition and microcirculation parameters in vitis vinifera extract supplemented and placebo subject before and after high intense training	This study will last 24 months (2013-2015)
Differences between oxidative stress biomarkers in vitis vinifera extract supplemented and placebo subject before and after high intense training	This study will last 24 months (2013-2015)
Differences between inflammation biomarkers in vitis vinifera extract supplemented and placebo subject before and after high intense training	This study will last 24 months (2013-2015)
Differences between adipokines in vitis vinifera extract supplemented and placebo subject before and after high intense training	This study will last 24 months (2013-2015)

Countries

Brazil

Contacts

Primary ContactM C G, MD

marianagoncalves.mg@gmail.com55 21 23340679

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026