Memory Disturbances
Conditions
Keywords
fMRI, Jaw tapping, Memory disorder, Mild cognitive impairment, MCI, Working memory
Brief summary
The purpose of this study is to examine the possibility of using jaw-tapping training as a self-exercise for developing memory and preventing dementia in elderly subjects with memory disturbances using functional magnetic resonance imaging (fMRI).
Detailed description
Right-handed female volunteers over the age of 50 years with subjective memory complaints are included in the study. Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders are excluded. The protocol was approved by the Institutional Review Board of university-based hospital. After administering the Seoul Neuropsychological Screening Battery (SNSB), Mini-Mental State Examination (MMSE) scores above 24 and Clinical Dementia Rating Scale (CDR) scores of 0 are considered subjective memory complaints (SMC), and MMSE scores above 23 and CDR scores of 0.5 are considered MCI. All subjects undergo two MRI scans. After the first MRI, the subjects are trained to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.
Interventions
BEHAVIORALJaw-tapping
to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.
Sponsors
Kyung Hee University Hospital at Gangdong
Kyunghee University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Right-handed female volunteers over the age of 50 years with subjective memory complaints
Exclusion criteria
* Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain activity of n-back task | up to 4 weeks | All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home. Pre- and post-test fMRI data during the n-back task are analyzed using statistical parametric maps of brain activation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brain activity of jaw-tapping task | baseline and 4 weeks | All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home. Pre- and post-test fMRI data during the jaw-tapping task are analyzed using statistical parametric maps of brain activation. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Performance scores of the n-back task | baseline and 4 weeks | One-back task performance of each subject is assessed by analyzing responses obtained during scanning. |
Countries
South Korea
Contacts
Primary ContactSeung-Yeon Cho, Ph.D
Outcome results
None listed