Hypoxia, Anesthetics, Conscious Sedation, Hypercapnia
Conditions
Keywords
Dexmedetomidine, Propofol, Hypoxic ventilatory response, Hypercapnic ventilatory response
Brief summary
The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
Detailed description
15 volunteers will be investigated for their hypoxic and hypercapnic ventilatory response during sedation with dexmedetomidine and propofol in a randomized cross-over study. 6 volunteers will be investigated for their repeated response to hypoxia and hypercapnia in order to validate the method.
Interventions
PROCEDUREHypoxic ventilatory response
PROCEDUREHypercapnic ventilatory response
Sponsors
Karolinska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Male 2. Age 18-40 3. American Society of Anesthesiologist´s classification (ASA) 1, i.e. healthy 4. No medication 5. No allergies 6. Non-smoker/no snuff, i.e. no nicotine intake 7. Normal weight, BMI \<26
Exclusion criteria
Snoring
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hypoxic ventilatory response | One day for each drug; before,during and after sedation with dexmeditomidine or propofol | Acute hypoxic ventilatory response,i.e. the ventilatory response to acute hypoxia measured as change in minute ventilation over change in peripheral oxygen saturation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hypercapnic ventilatory response | One day for each drug; Before, during and after sedation with dexmedetomidine or propofol | The acute ventilatory response to hypercapnia, i.e. change in minute ventilation over change in end-tidal carbon dioxide |
Other
| Measure | Time frame | Description |
|---|---|---|
| upper airway obstruction | One day for each drug: Before, during and after sedation with dexmedetomidine or propofol | Objective signs of upper airway obstruction, e.g. Interruption of airflow at the same time as breathing movements of the thoracic wall, paradoxal breathing, increased airway resistance |
| Plasma concentration | One day for each drug; At target sedation | Plasma concentration of dexmedetomidine or propofol |
| Sedation level | One day; During the whole experimental procedure | Sedation level will be measured as Richmond Agitation Sedation Scale(RASS) the observer's assessment of alertness/sedation scale (OAA/S) |
| Bispectral index | One day; During the whole experimental procedure | Bispectral index (BIS) gives a number between 0-100 |
Countries
Sweden
Outcome results
None listed