Bioavailability
Conditions
Brief summary
The objective of this study is to investigate the absorption of menaquinone-7 from a nutrient-enriched dairy product compared to a general dairy product enriched with menaquinone-7 and a menaquinone-7-containing supplement.
Detailed description
In an earlier study, beneficial effects of a nutrient-enriched dairy product on vitamin K-status were observed. The study product contained menaquinone-7 (MK-7) and omega-3 fatty acids for vascular health and extra minerals and antioxidants to support general health. It was the first time that such low dose of MK-7 (50 µg) could significantly improve vascular and general vitamin K-status already after short-term treatment. From the results of this study, it was assumed that the matrix of the dairy product and/or other components in the product, in which the vitamin was offered, contributed to optimal absorption and availability of vitamin K2. In this new study, the uptake and efficacy of MK-7 from the nutrient enriched product is investigated and compared to the uptake and efficacy from a MK-7-containing supplement and a basic dairy product enriched with MK-7.
Interventions
DIETARY_SUPPLEMENTMK-7 containing capsule
DIETARY_SUPPLEMENTbasic yogurt enriched with MK-7
DIETARY_SUPPLEMENTnutrient-enriched yogurt with MK-7
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Apparently healthy men and postmenopausal women between 45 and 65 years old * Subjects with body weight and height according to BMI between 20 and 30 kg/m2 * Subjects of Caucasian race * Subject has given written consent to take part in the study
Exclusion criteria
* Subjects with hypertension * Subjects with hypercholesterolemia * Subjects with (a history of) metabolic or gastrointestinal disease * Subjects presenting chronic degenerative and/or inflammatory disease * Subjects with (a history) of diabetes mellitus * Abuse of drugs and/or alcohol * Subjects receiving corticosteroid treatment * Subjects using oral anticoagulants and subjects with clotting disorders * Subjects using blood pressure-lowering medication * Subjects using cholesterol-lowering medication * Subjects using multivitamins or vitamin K supplements * Subjects consuming high amounts of vitamin K-containing food products * Subjects with cow's milk allergy and lactose intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in plasma MK-7 concentration after intervention between the three study groups | baseline and 6 weeks |
Secondary
| Measure | Time frame |
|---|---|
| The change in circulating markers of vitamin K-status, undercarboxylated osteocalcin and desphospho-uncarboxylated matrix Gla-protein, after intervention between the three study groups. | baseline and 6 weeks |
Other
| Measure | Time frame |
|---|---|
| The change in circulating vitamin D (25-hydroxy-vitamin D) after intervention between the study groups. | baseline and 6 weeks |
Countries
Netherlands
Outcome results
None listed