Pain
Conditions
Keywords
Local analgesia system, Ropivacaine, Analgesic efficacy after operation, Postoperative
Brief summary
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain.The use of appropriate postoperative analgesia in patients with thoracolumbar surgery is beneficial to postoperative recovery. Infusions of local anaesthetic via multilumen catheters that deliver directly to wound sites have been used for postoperative analgesia in procedures. Reducing the morbidity from both pain and nausea will make the mode of analgesia a better tolerated and more palatable option for patients. The aim of this study is to examine the effects of using local anaesthetic infusion catheters following posterior thoracolumbar surgery, and compares the outcomes of patients managed using intravenous analgesia pump infusion of systemic opioids.
Detailed description
All 71 adult patients were prospectively included and randomized to either the local (L) group (n=35) or the intravenous (V) group (n=36) by using a random number table: the test group were treated with local analgesia infusion pump of 0.33% ropivacaine through the wound for postoperative analgesia, while the control group were treated with intravenous analgesia pump infusion of flurbiprofen axetil,palonosetron, pentazocine. At 2, 4, 6, 12, 24, 36, 48 hours after operation, postoperative pain visual analogue scale(VAS) scores and sedation Ramsay scores were used to evaluate the level of pain and sedation, and investigators documented the comprehensive evaluation of patients with pain control system, and the incidence of adverse reactions. At 24, 48 hours investigators observed the wound whether inflammation and exudation or not, and the removal of penetration catheter sent to clinical laboratory for bacterial culture. Investigators also recorded the length of time to discharge and called to ask pain conditions at the first 3 months.
Interventions
OTHERlocal
This group uses local analgesia infusion pump of 0.33% ropivacaine 250ml through the wound for postoperative analgesia.
OTHERintravenous
This group is treated with intravenous analgesia pump infusion of flurbiprofen axetil 150mg,palonosetron 0.5mg,pentazocine 240mg.
DRUG0.33% ropivacaine 250ml
DRUGflurbiprofen axetil 150mg,palonosetron 0.5mg,pentazocine 240mg.
Sponsors
Guangzhou General Hospital of Guangzhou Military Command
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. ASA Ⅰ \ Ⅱ patient undergoing elective posterior thoracolumbar operation 2. between 18 and 70 years of age
Exclusion criteria
1. A history of cardiopulmonary disease, liver and kidney dysfunction, abnormal coagulation 2. Preoperative use of analgesic drugs 3. A allergy history of ropivacaine and polyurethane material
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pain | 48 hours postoperation | Up to 48 hours after operation,postoperative pain visual analogue scale(VAS) scores are used to evaluate the level of pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sedation | 48 hours postoperation | At 2, 4, 6, 12, 24, 36, 48 hours after operation,sedation Ramsay scores are used to evaluate the level of sedation. |
| comprehensive evaluation | 48 hours postoperation | Investigators document the comprehensive evaluation of patients with pain control system,including the incidence of adverse reactions. |
Countries
China
Outcome results
None listed