Advanced Rectal Cancer
Conditions
Keywords
rectal cancer, rectal adenocarcinoma, photodynamic therapy, chemothrapy
Brief summary
This research is a prospective randomized controlled trial.It aimed to determine longterm outcomes and factors associated with increased survival after photodynamic therapy (PDT) through colonscopy compared with chemotherapy alone in patients presenting with advanced rectal cancer.
Interventions
PROCEDUREPhotodynamic therapy
Each patient to whom PDT was offered underwent a specific, detailed educational process by a dedicated team member(P.B., P.J., or K.E.), after which informed consent was obtained.Porfimer sodium (Photofrin; Axcan Pharma Inc, Quebec, Canada)was used as a photo sensitizing agent, administered intravenously at a dose of 2 mg/kg body weight 48 hours before illumination.A diode laser system (InGaAIP Laser Diode; Diomed Inc, An-dover, MA) with a maximum power output of 2000 mW and a wavelength of 633+-3 nm was used as a light source, delivered through a 3.0-m length fiber having a 2.5-cm-long cylindrical diffuser at its distal end (Pioneer Optics, Windsor Locks, CT).
Sponsors
li xiong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* 1.Patients with advanced rectal cancer 2.Patients are willing to join in this clinical trial.
Exclusion criteria
* 1.Patients with advanced rectal cancer can not suffer PDT procedure. 2.Allergy to photosensitizer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rate | one month |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival | One month |
Other
| Measure | Time frame |
|---|---|
| Quality of life | one month |
Countries
China
Outcome results
None listed