Electroconvulsive Therapy, Major Depression
Conditions
Keywords
sevoflurane, ketamine, QT interval
Brief summary
The aim of this study was to evaluate the effect of sevoflurane or ketamine on the QTc and Tp-e interval during in patients with major depression.
Detailed description
Patients enrolled in the study are randomly allocated by computer-generated random numbers to receive either sevoflurane or ketamine for their initial ECT session. They subsequently receive an alternative study drug in their next session, continuing to alternate between drugs at each session until the sixth session. In group S, sevoflurane are initiated at %8 sevoflurane for anesthesia induction and maintained at 2% to %4 until the electrical stimulus is delivered, In group K, ketamine are given to 1mg/kg ıv bolus. Electrical stimulus is delivered via bilateral frontotemporal electrodes.The mean arterial pressure (MAP), HR, and ECG are recorded before anesthetic induction (T1), after anesthetic induction (T2) and at 0, 1, 3, 10 min after the seizure ended (T3, T4, T5 and T6, respectively).The QT interval and Tp-e interval are measured by one author, who was unaware of group allocation.
Interventions
DRUGSevoflurane
sevoflurane was initiated at %8 sevoflurane for anesthesia induction and maintained at 2% to %4 until the electrical stimulus was delivered
DRUGKetamine
ketamine was given to 1mg/kg ıv bolus
Sponsors
Inonu University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Unpremedicated * American Society of Anesthesiologists (ASA) I-II the patients * Major depressions patients scheduled for ECT sessions
Exclusion criteria
* pregnant * with permanent pacemakers, * diabetes mellitus, * atrial fibrillation, * electrolyte imbalance, * patients taking antiarrhythmics and β-blockers.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation Of QT interval | 10 minutes | ECG were recorded before anesthetic induction (T1), after anesthetic induction (T2) and at 0, 1, 3, 10 min after the seizure ended (T3, T4, T5 and T6, respectively)during ECT anesthesia with sevoflurane and ketamine.The QT interval was measured by one author, who was unaware of group allocation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of Tp-e interval | 10 minutes | ECG were recorded before anesthetic induction (T1), after anesthetic induction (T2) and at 0, 1, 3, 10 min after the seizure ended (T3, T4, T5 and T6, respectively)during ECT anesthesia with sevoflurane and ketamine.The Tp-e interval was measured by one author, who was unaware of group allocation. |
| Seizure durations | 120 seconds | The duration of the EEG seizure was recorded from the EEG trace, and the peak heart rate (HR) during the convulsion was recorded from the ECG. |
Countries
Turkey (Türkiye)
Outcome results
None listed