Type 2 Diabetes
Conditions
Brief summary
The trough concentration of metformin will be examined in monozygotic and dizygotic twins. Current twin study will determine the total weight of genetics on the trough concentration of metformin.
Interventions
DRUGMetformin
6 days treatment with metformin to steady-state
Sponsors
University of Southern Denmark
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-40 years * Both twins has to be included * Dizygotic twin pairs has to be same sex * Informed consent given * Healthy condition
Exclusion criteria
* Chronical/daily alcohol abuse * Hypersensitivity to metformin * Ingestion of drugs containing topiramate or x-ray contrast fluids * For women: Positive pregnancy test/breastfeeding at the beginning of the trial. No use of safe anticonceptives
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heritability | After 6 days of metformin treatment | The trough concentrations of metformin in twin pairs will be used to determine the effect of heritability on metformin trough concentrations. This will give insight to the weight that genetic factors have on metformin pharmacokinetics at steady-state. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Single nucleotide polymorphisms (SNPs) | After 6 days treatment with metformin | The effect of SNPs on trough metformin concentration |
Countries
Denmark
Outcome results
None listed