Wound Healing, Wound Infection
Conditions
Keywords
Wound healing, Wound infection, Resin salve, Medical honey
Brief summary
In recent years, salve prepared from Norway spruce (Picea abies) resin and refined honey from manuka myrtle (Leptospermum scoparium), has successfully been used in medical context to treat both acute and chronic surgical wounds. The objective of this prospective, randomized and controlled clinical trial is to investigate healing rate and healing time of surgical wounds in patients, who have undergone peripheral vascular surgery, and whose complicated wounds are candidate for topical treatment with the resin or honey. In addition, factors contributing with delayed wound healing, antimicrobial properties, safety and cost-effectiveness of the resin salve and medical honey will be analyzed.
Interventions
DEVICEAbilar 10% resin salve
The resin salve may be spread directly onto the wound, after which the area is covered with a bandage suitable for local wound care. The bandage prohibits salve from moving away from the wound area. If the skin condition is more widespread or contains cavities or fistulae, the salve may be spread as a film with a thickness of at least 1 mm onto a gauze or gauze ribbon that is then used to fill the cavity or fistulae channel. Bandages are changed every 1-3 days, depending on the degree of infection and amount of wound secretion.
DEVICEActivon Tube 25 g
Wound care with the medical honey is carried out in the same manner than the resin salve treatment: honey may be spread directly onto the wound and the wound area is covered with a bandage suitable for local wound care. Similarly, if the skin condition is more widespread or wound contains cavities or fistulae, the medical honey may be spread as a film with a thickness of at least 1 mm onto a gauze or gauze ribbon that is then used to fill the cavity or fistulae channel. Bandages are changed every 1-3 days, depending on the severity of infection and amount of wound secretion.
Sponsors
Kuopio University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Infected of non-infected acute or chronic wound after vascular surgery. * Need for topical wound care. * Need for wound healing follow-up at the surgical outpatient department.
Exclusion criteria
* Life expectancy less than 6 months. * Advanced malignant disease. * Need for extensive surgical wound revision or skin transplantation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Wound Healing | 6 months | Healing rate of acute or chronic surgical wound within 6 months after vascular surgery (%). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Contributors for Wound Healing | 6 months | Contributors in terms of risk ratio (RR) to delayed wound healing. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Other Pre-specified Outcome Measure | 6 months | * Safety and compliance related with the resin salve or medical honey treatment. * Eradication rate of cultured pathogenic bacteria from wounds within 6 months. * Overall costs of resin salve and medical honey treatment within 6 months. |
Countries
Finland
Outcome results
None listed