Parkinson's Disease
Conditions
Brief summary
The aim of the study is to train patients with Parkinson's Disease to increase activity in a brain area that is involved in the control of motor functions with the use of a technique called real-time fMRI neurofeedback (NF) along with regular physical exercise. This will be a randomised and controlled clinical trial to evaluate the benefits of a novel treatment. The investigators expect NF training along with physical exercise practise to better improve motor functions compared to physical exercise alone.
Interventions
OTHERNeurofeedback and Physical Exercise
OTHERPhysical Exercise
Sponsors
Cardiff University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* People with Parkinson's Disease * Hoehn and Yahr stages 1-3 of the disease
Exclusion criteria
* Patients with dementia or significant comorbidity * those who fail the safety screening to go into an MRI scanner * those who cannot travel to the University
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline in the 'Movement Disorder Society - Unified Parkinson's Disease Rating Scale' (MDS-UPDRS) | Change from Baseline in the 'Movement Disorder Society - Unified Parkinson's Disease Rating Scale' (MDS-UPDRS) in 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline in the 'Parkinson's Disease Questionnaire 39' (PDQ-39) | Change from baseline in the 'Parkinson's Disease Questionnaire 39' (PDQ-39) at 4 weeks |
| Change from baseline in the 'Actigraph' | Change from baseline in the 'Actigraph' at 12 weeks |
| Change from baseline in the 'GaitRite' | Change from baseline in the 'GaitRite' at 12 weeks |
Countries
United Kingdom
Outcome results
None listed