Hemodialysis Patients
Conditions
Keywords
hemodialysis, microcirculation, physical perdialytic activity, cycling
Brief summary
Chronic kidney disease (CKD) is associated with high level of peripheral arterial disease (PAD). This could lead wounds, infections then amputations or deaths by impairment of the peripheral cutaneous perfusion. Medical therapies are presently unable to cure, but only slow down these disorders. Impact of exercise and lower extremity PAD rehabilitation is decreased by the significant inactivity of the chronic hemodialysis patients. Recently, many studies have shown several various favorable effects of the perdialytic physical activity. There is currently no data about effects of the perdialytic activity on the lower extremity perfusion. The aim of this clinical study is to show the impact of three months perdialytic cycling on the microcirculation, in chronic hemodialysis patients. Primary outcome will be the increase of cutaneous perfusion, assessed by measuring transcutaneous oxygen pressure (tcPO2) on about twenty patients.
Interventions
OTHERThree months of regular perdialytic physical activity (cycling)
Cycling, in lying position, at a rate of thirty minutes per dialysis session (three a week), regardless of performance
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients performing chronic hemodialysis for more than 3 months * Adult aged \> or = 18 years old * Information letter delivered to subjects * Written free informed consent * Clinically stable patients * Voluntary patients to perform 30 minutes cycling per dialysis session * Social French Security Affiliated subjects
Exclusion criteria
* Subjects without inclusion criteria * Pregnant women * Subjects protected by the law * Physical impossibility to achieve exercise * Medical contraindication to perform physical exercise
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase of cutaneous lower extremity perfusion. | TcPO2 will be performed at the inclusion and just after the end of the three month study period |
Secondary
| Measure | Time frame |
|---|---|
| Related quality of life | at the inclusion and after the end of the three month study period |
| Appetite (score) | at the inclusion and after the end of the three month study period |
| Daily activity (Seven days pedometers) | at the inclusion and after the end of the three month study period |
| Vascular assessment : Doppler and Index of systolic blood pressure | At the inclusion and after the end of the three month study period |
| nutritional biological status (creatinin, albumin and transthyretin protein level) | at the inclusion and after the end of the three month study period |
| strength (handgrip test) | at the inclusion and after the end of the three month study period |
| Protein intake (n-PCR) | at the inclusion and after the end of the three month study period |
Countries
France
Outcome results
None listed