Multiple Sclerosis
Conditions
Keywords
transcutaneous electrical nerve stimulation, sensitivity, multiple sclerosis,Reeducation through labor tactile discrimination
Brief summary
Sensory disorders in patients with multiple sclerosis are among the most common symptoms encountered. A functional impairment based on sensory disorders of the hand. The hand is a sensory organ that transmits the cerebral cortex protopathic sensitive information, proprioceptive or epicritiques. The view-hand association plays an important role in the understanding of the environment. Its exploratory use remains an essential and voluntary basis. The process of recognition of the object passes through manipulation, but operates instantaneously. The brain is able to do a quick summary of the information it receives to determine the nature of the manipulated object. The exploration takes a posteriori, the brain can then determine the details component object (texture, shape, composition, temperature and weight). Neurophysiological mechanisms that would explain the analgesic effects of transcutaneous electrical nerve stimulation (TENS) are not fully understood. Several theories underlying its use as a neuromodulator of pain. The gate control theory has led to the development of TENS devices. Recruitment of myelinated, large caliber, by the TENS electrodes afferent fibers increases the control exerted on spinal level, thereby inhibiting the action of afferent fibers of small caliber related to nociception. This stimulation strengthens the blocking of gate at the corresponding cell bodies of spinothalamic tract and reduces the transmission of nociceptive impulses to the spinal cord dorsal horn. This is segmental presynaptic inhibition depends on the area and stimulated. The objective of this study is to improve the quality of life through improved sensitivity disorders of the hand in patients with MS, thanks to reeducation of the hand.
Interventions
DEVICEequipment rehabilitation stereognosis
DEVICETENS
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with relapsing remitting MS defined according to Poser criteria \[9\] and McDonald \[5\]. * Age ≥ 18 years, male or female sex * Patients with sensory disorders interesting hands, evidenced by clinical examination objective. * Patients with an EDSS between 2 and 4 with functional sensitivity parameter ≥ 2. * Patients affiliated to a social security scheme. * Patients signed informed consent for the study.
Exclusion criteria
* Patients with other central or peripheral disorders may affect the sensitivity of the hand. * Patients with allodynia in the study area * Patients with a motor and / or deficit cerebellar ataxia of the upper limbs. * Patients treated with psychotropic or antiepileptic drugs. * Patients for whom a flare occurred affecting the sensitivity of the hand, within 30 days before enrollment. * Patients holders of an active implantable medical device. * Pregnant women and vulnerable patient population.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Compare quality of life between baseline and procedure | frist day, 1 month and 3 month | Improve the quality of life through improved sensitivity disorders of the hand in patients with MS, thanks to reeducation of the hand. Unit of mesure: scale MusiQoL |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Compare the performance during functional tests between baseline and procedure | first day, 1 month and 3 month | Improve performance of MS patients during functional tests in patients undergoing rehabilitation treatment compared to the control group. Using picking up test and thr Nine Hole Peg Test |
| Compare the improvement clinically sensitive target from baseline procedure | first day, 1 month and 3 month | Improve clinically sensitive target of MS patients through a rehabilitation treatment compared to the control group. Using the Threshold pressure, the Threshold to the vibration and the Weber test. |
Countries
France
Outcome results
None listed