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Selective Ultrasound Screening for DDH 1991-2006

Selective Ultrasound Screening for Developmental Hip Dysplasia: Effect on Management and Late Detected Cases. A Prospective Survey During 1991-2006.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT01866527
Enrollment
81564
Registered
2013-05-31
Start date
1991-01-31
Completion date
2012-08-31
Last updated
2013-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Developmental Dysplasia of the Hip

Keywords

Developmental dysplasia of the hip,, DDH,, avascular necrosis,, late detected cases

Brief summary

Early treatment is considered essential for developmental dysplasia of the hip (DDH), but the choice of screening strategy is debated. The investigators evaluated the effect of a selective ultrasound (US) screening programme. All infants born in a defined region during 1991-2006 with increased risk of DDH, i.e. clinical hip instability, breech presentation, congenital foot deformities or a family history of DDH, were subjected to US screening at age one to three days. Severe sonographic dysplasia and/or dislocatable/dislocated hips were treated with abduction splints. Mild dysplasia and/or pathological instability, i.e. not dislocatable/dislocated hips were followed clinically and sonographically until spontaneous resolution, or until treatment became necessary. The minimum observation period was 5,5 years.

Detailed description

Of 81564 newborns, 11539 (14,1%) were identified as at risk, of which 11190 (58% girls) were included for further analyses. Of the 81564 infants, 2433 (3•0%) received early treatment; 1882 (2,3%) from birth and 551 (0,7%) after six weeks or more of clinical and sonographic surveillance. Another 2700 (3,3%) normalised spontaneously after watchful waiting from birth. Twenty-six infants (0,32 per 1000, 92% girls, two from the risk group) presented with late subluxated/dislocated hips (after one month of age). Another 126 (1,5 per 1000, 83% girls, one from the risk group) were treated after isolated late residual dysplasia. Thirty-one children (0,38 per 1000) had surgical treatment before age five years. Avascular necrosis was diagnosed in seven of all children treated (0.27%), four after early and three after late treatment. Interpretation The first 16 years of a standardised selective US screening programme for DDH resulted in acceptable rates of early treatment and US follow-ups, and low rates of late subluxated/dislocated hips compared to similar studies.

Interventions

None listed

Sponsors

Helse Vest
CollaboratorOTHER
University of Bergen
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* born at Haukeland University hospital January 1991-December 2006

Exclusion criteria

* Children with DDH due to neuromuscular syndromes were excluded.

Design outcomes

Primary

MeasureTime frameDescription
late dislocated or subluxated hipsfirst 5 years of lifelate detected after 1 month of life, requiring treatment

Secondary

MeasureTime frameDescription
Number of participants who receive ultrasound follow-up for 6 weeks or morefirst months of lifeNumber of participants who receive ultrasound follow-up (i.e sonographic surveillance) for 6 weeks or more
early treatmentfirst months of lifeabduction treatment for DDH
first surgical treatmentfirst five years of lifethe need for a first surgical treatment the first 5 years of life (closed and open reductions, osteotomies)
avascular necrosis of femoral headfirst five years of lifeavascular necrosis of femoral head as complication to treatment

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026